The Second Mizukage was the head ninja of Hidden Mist Village. He had a long standing rivalry with Muu the Nidaime Tsuchikage. Both men eventually met in battle and killed each other in the process.
After Kabuto joined forces with Akatsuki, he resurrected many dead ninja to fight at their side using Edo Tensei. Nidaime Mizukage was dispatched along with Sandaime Raikage, Nidaime Tsuchikage and Yondaime Kazekage. Nidaime Mizukage voiced discontent at having to work with his rival Muu, voicing that had he control of his body, he would kill Tsuchikage once again.